Spam bots are probably finding the user URL (http://example.com/user) and the subsequent 'create account' link. 

You need to prevent anonymous users from creating accounts.

In Drupal 6 visit admin/user/settings
In Drupal 7 visit admin/config/people/accounts

Alternatively, if you do wish to have anonymous users create accounts but prevent spam, you could add a captcha to the account creation form.

Carl Wiedemann
Website design and development consulting
carl.wiedemann@gmail.com | skype: c4rlww