[support] Server-wide Drupal install: best practices?

Hi, I'm doing some new-year server housekeeping and I'd like to streamline my current Drupal setup. What's the best way to run Drupal in a cPanel server with several domains and customer accounts? - A single, server-wide Drupal instance? - A Drupal instance for each customer cPanel account? - A Drupal instance for each customer domain? I'm already using the multisite feature for some domains/subdomains in a specific cPanel account, but I will appreciate any comments and suggestions for going further. Kind regards. -------------------------------------------------------------------- Albert Cuesta