[support] Varnish

Dear All I am planning to use Varnish 3.0.3 with Drupal 7.15. I hope both of these are compatible.., any input highly appreciated. Varnish binds to two ports 6081, 6082. I read somewhere we need to run Varnish in port 80 and apache in 8080 and accordingly we need to configure. If I do that, I am unable to access the site. Is it required to open port 8080 in firewall. Thanks -Kamal